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Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
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The use of structure-based drug design to optimise protein-ligand interactions
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The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
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Electrochemically enabled synthesis of substituted isoxazolines
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αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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New methods for the synthesis of pharmaceutical azacycles
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New hydrogen atom transfer methodologies for synthesis
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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