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GlaxoSmithKline
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Risultati della ricerca
Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
Creatore:
Whitehurst, Ben.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
Creatore:
Campos, Sébastien André.
Data:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Automated, quantitative process analysis by NMR
Creatore:
Watson, Simon Andrew.
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
Creatore:
Barrett, Victoria J.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
Creatore:
Wood, Susanna Helen
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Effects of OGG1 activation on mitochondrial function in response to oxidative stress
Creatore:
Katchur, Steven R.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences.
New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
Creatore:
Teague, Simon Peter
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Development of small molecule splice-switchers as inducers of apoptosis
Creatore:
Campbell, Emma
Data:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Approaches to lead generation for idiopathic pulmonary fibrosis targets
Creatore:
Duffy, Emma.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
New route investigation and process development in the synthesis of GSK221149
Creatore:
Roberts, Alastair
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of targeted BET inhibitors
Creatore:
Robertson, Craig Michael
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development towards prospective modelling of in vivo rabbit QTc prolongation
Creatore:
Lewis, Gareth John
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Studies and improvement of molecular docking methods in rigid and flexible receptors
Creatore:
Le Gall, Armelle
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Development of the C-methyltransferases NovO and CouO for biocatalytic Friedel-Crafts alkylation
Creatore:
Sadler, Joanna C.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Structure-guided approaches to the design of novel autotaxin inhibitors
Creatore:
Potjewyd, Frances
Data:
2016
Funder:
Engineering and Physical Sciences Research Council
and
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
Creatore:
Fallon, David
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
Creatore:
Mahammed, Farjana
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
Creatore:
Baker, Blake Jamie Mark
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Application of bioisosteres to modulate molecular properties in medicinal chemistry
Creatore:
Measom, Nicholas
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of chemical probes for non-BET bromodomains
Creatore:
Clegg, Michael A.
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of chemical probes for non-BET bromodomains
Creatore:
Theodoulou, Natalie
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
Creatore:
White, Gemma Victoria
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
Creatore:
Summers, Declan M.
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
Creatore:
Campbell-Crawford, Matthew H. J.
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of epigenetic mechanism inhibitors
Creatore:
Campbell, Matthew.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
Creatore:
Colleville, Aymeric Pierre.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
Creatore:
Harrison, Zoë A.
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
New hydrogen atom transfer methodologies for synthesis
Creatore:
Turner, Oliver
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
Creatore:
Priestner, John C.
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The use of contemporary chemoproteomic techniques in antimalarial target identification
Creatore:
Tucker, Jessie S.
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Preclinical development of a treatment for systemic lupus erythematosus
Creatore:
Murray, Erin
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of novel epigenetic modulators
Creatore:
Jones, Katherine
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
Creatore:
Wellaway, Christopher Roland
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of chemo- and regioselective reactions of boron systems
Creatore:
Clohessy, Thomas A.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New chemical approaches for the development of targeted protein degradation
Creatore:
Lithgow, Hannah
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Targeted protein degradation as a new approach to drug discovery
Creatore:
Tinworth, Christopher Patrick
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
Creatore:
Hayhow, Thomas G.
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
Creatore:
Tape, Daniel Terence.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
Creatore:
Hardy, Charlotte.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
Creatore:
Lacroix, Yannick
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
Creatore:
Shah, Rishi R.
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New methods for the synthesis of pharmaceutical azacycles
Creatore:
Clark, Peter
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Understanding the hepatic disposition of statins to improve predictions of safety and efficacy
Creatore:
Heslop, Teresa Louise
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
Creatore:
Snell, Richard
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
A medicinal chemistry approach towards brodomain epigenetic modulators
Creatore:
Law, Robert Peter
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
Creatore:
Diallo, Hawa
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
Creatore:
Williams, Jason D.
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Studies towards the synthesis and labelling of bioactive peptides
Creatore:
Stewart, Sam
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel approaches targeting phosphoinositide 3-kinase delta
Creatore:
Spencer, Jonathan Andrew
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
Creatore:
Sanderson, James
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
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Biotechnology and Biological Sciences Research Council
1
Carnegie Trust for the Universities of Scotland
1
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis
1
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1
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Department of Pure and Applied Chemistry
53
Department of Pure and Applied Chemistry.
20
Strathclyde Institute of Pharmacy and Biomedical Sciences
6
Strathclyde Institute of Pharmacy and Biomedical Sciences.
2
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