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Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
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The regulation of Toll-like receptor (TLR)-stimulated inducible inhibitory kappa B kinase (IKK-i) expression in murine macrophages
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Disrupting inhibitory-kappaB kinase (IKK)-Aurora kinase signalling in prostate cancer cells
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Regulation of human CXCL12 expression by IKKα in bone cancer and cancer associated fibroblasts derived from clinical specimens obtained from breast cancer patients
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Development of novel allosteric regulators of proteinase-activated receptors
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Characterisation of microglia's inflammatory response and investigation of the effect of mesenchymal stem cells-conditioned media
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The role of mitogen-activated protein kinase phosphate-2 (MKP-2) in macrophage functions
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Characterisation of novel compounds as antagonists of protease-activated receptor-2 (PAR2)
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Examination of IKKα inhibitors as novel anti-panceatic cancer drugs
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Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
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