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Computer-aided drug design of bicyclic-derived BRD4 inhibitors
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Synthetic approaches to heterocyclic systems of pharmaceutical relevance
2 di 25
Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
3 di 25
Application of bioisosteres to modulate molecular properties in medicinal chemistry
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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Application of computer vision in industrially important reactions
6 di 25
Development of new chemical tools as crop protecting agents
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Novel approaches targeting phosphoinositide 3-kinase delta
8 di 25
The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
9 di 25
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
10 di 25
Studies towards the synthesis and labelling of bioactive peptides
11 di 25
Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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Structure-guided approaches to the design of novel autotaxin inhibitors
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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Investigation of LPA₁ receptor antagonism / ATX inhibition by a scaffold hopping aproach and SAR analysis
15 di 25
The development of natural products as phytotoxic leads for herbicide discovery
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Development of novel allosteric regulators of proteinase-activated receptors
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Investigations into the generation and pleiotropic reactivity modes of the nitrile imine 1,3-dipole
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Approaches to lead generation for idiopathic pulmonary fibrosis targets
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New methods for the construction of selectively difluorinated carbocycles
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The development of novel organocatalytic and transition-metal catalysed methodologies for amide bond formation
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The design and synthesis of molecular tools for probing biological function
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Expedient access to C-aryl linked saturated heterocyclic motifs
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The development of small molecule inhibitors for fibrosis drug discovery
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Evaluating the application and limitations of bio-based solvents within organic synthesis
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