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Synthesis and biological evaluation of novel small molecule bromodomain inhibitors
创造者:
Stafford, Kayleigh
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Exploiting DNA-encoded library : technology for the discovery of novel antibody recruiting molecules against LOX-1
创造者:
Macfarlane, Katherine F.
日期:
2022
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Approaches to lead generation for idiopathic pulmonary fibrosis targets
创造者:
Duffy, Emma
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
创造者:
Willis, Robert
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
The development of small molecule inhibitors for fibrosis drug discovery
创造者:
Miller, Lisa Margaret
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
创造者:
Campos, Sébastien André
日期:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Automated, quantitative process analysis by NMR
创造者:
Watson, Simon Andrew
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of the C-methyltransferases NovO and CouO for biocatalytic Friedel-Crafts alkylation
创造者:
Sadler, Joanna C.
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
创造者:
Harrison, Zoë A.
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Studies and improvement of molecular docking methods in rigid and flexible receptors
创造者:
Le Gall, Armelle
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Effects of OGG1 activation on mitochondrial function in response to oxidative stress
创造者:
Katchur, Steven R.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Understanding the hepatic disposition of statins to improve predictions of safety and efficacy
创造者:
Heslop, Teresa Louise
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
创造者:
Whitehurst, Ben
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of epigenetic mechanism inhibitors
创造者:
Campbell, Matthew
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New methods for the construction of selectively difluorinated carbocycles
创造者:
McCarter, Adam William
日期:
2018
Funder:
GlaxoSmithKline
and
Carnegie Trust for the Universities of Scotland
Department, School or Faculty:
Department of Pure and Applied Chemistry
Single electron transfer in organic synthesis targeted towards sustainable manufacture
创造者:
Barham, Joshua Philip
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Synthetic approaches to heterocyclic systems of pharmaceutical relevance
创造者:
Green, Luke
日期:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
创造者:
Hardy, Charlotte
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
创造者:
Summers, Declan M.
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
创造者:
Colleville, Aymeric Pierre
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New route investigation and process development in the synthesis of GSK221149
创造者:
Roberts, Alastair
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development towards prospective modelling of in vivo rabbit QTc prolongation
创造者:
Lewis, Gareth John
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
创造者:
Lacroix, Yannick
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of novel epigenetic modulators
创造者:
Jones, Katherine
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
创造者:
Shaalan, Youssef
日期:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Structure-guided approaches to the design of novel autotaxin inhibitors
创造者:
Potjewyd, Frances
日期:
2016
Funder:
Engineering and Physical Sciences Research Council
and
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
创造者:
Buchanan, Helena Stubbe
日期:
2021 and 2020
Funder:
GlaxoSmithKline
and
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis
Department, School or Faculty:
Department of Pure and Applied Chemistry
A medicinal chemistry approach towards brodomain epigenetic modulators
创造者:
Law, Robert Peter
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
创造者:
White, Gemma Victoria
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of small molecule splice-switchers as inducers of apoptosis
创造者:
Campbell, Emma
日期:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
创造者:
Tape, Daniel Terence
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigating and exploiting best practices in hit identification and hit to lead chemistry
创造者:
Borthwick, Jennifer
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
创造者:
Teague, Simon Peter
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
The development of chemo- and regioselective reactions of boron systems
创造者:
Clohessy, Thomas A.
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Targeted protein degradation as a new approach to drug discovery
创造者:
Tinworth, Christopher Patrick
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
创造者:
Priestner, John C.
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The use of contemporary chemoproteomic techniques in antimalarial target identification
创造者:
Tucker, Jessie S.
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of chemical probes for non-BET bromodomains
创造者:
Clegg, Michael A.
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Application of bioisosteres to modulate molecular properties in medicinal chemistry
创造者:
Measom, Nicholas
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Catalytic methods for etherification reactions
创造者:
Whitaker, Luke
日期:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Studies towards the synthesis and labelling of bioactive peptides
创造者:
Stewart, Sam
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
创造者:
Hayhow, Thomas G.
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of chemical probes for non-BET bromodomains
创造者:
Theodoulou, Natalie
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
创造者:
Hyslop, Julia
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New methods for the synthesis of pharmaceutical azacycles
创造者:
Clark, Peter
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
创造者:
Fallon, David
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
创造者:
Mahammed, Farjana
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
创造者:
Campbell-Crawford, Matthew H. J.
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of small molecule bromodomain inhibitors
创造者:
Lucas, Simon Christopher Cranko Alcock
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of targeted BET inhibitors
创造者:
Robertson, Craig Michael
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
创造者:
Williams, Jason D.
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel approaches targeting phosphoinositide 3-kinase delta
创造者:
Spencer, Jonathan Andrew
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
创造者:
Diallo, Hawa
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of lysine acylating small molecules for covalent kinase inhibition
创造者:
Fournier, Julie C. L.
日期:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigating streptomyces clavuligerus linear replicons for improved clavulanic acid production
创造者:
Mohit, Elmira
日期:
2023 and 2024
Funder:
Biotechnology and Biological Sciences Research Council
,
GlaxoSmithKline
, and
Industrial Biotechnology Innovation Centre
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
创造者:
Wellaway, Christopher Roland
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
创造者:
Snell, Richard
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
创造者:
Barrett, Victoria J.
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
创造者:
Baker, Blake Jamie Mark
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Chan-Lam animation studies : solving the chemotype reactivity issue
创造者:
Vantourout, Julien
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
创造者:
Shah, Rishi R.
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New hydrogen atom transfer methodologies for synthesis
创造者:
Turner, Oliver
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Increasing the saturation of BET inhibitors
创造者:
Dixon, Joseph Edward
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
创造者:
Wood, Susanna Helen
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Computational modelling of enzyme activity to speed up biocatalyst redesign
创造者:
Dréanic, Marie-Pierre
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
创造者:
Sanderson, James
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Preclinical development of a treatment for systemic lupus erythematosus
创造者:
Murray, Erin
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Expanding the scope of asymmetric redox-relay oxidative Heck transformations
创造者:
Bonfield, Holly E.
日期:
2022
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development and understanding of rhodium-catalysed conjugate arylation for process chemistry applications
创造者:
Lovelock, Stephen
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
创造者:
Hooper-Greenhill, Edward
日期:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
The use of structure-based drug design to optimise protein-ligand interactions
创造者:
Bertrand, Sophie
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
创造者:
Anderson, Niall A.
日期:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
创造者:
Thompson, James
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
创造者:
Griffiths, Robert Joseph
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
创造者:
Taylor, Jonathan Andrew
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
创造者:
Tame, Christopher J.
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
创造者:
Orr, David George Alexander
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
创造者:
Miah, Afjal Hussain
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Electrochemically enabled synthesis of substituted isoxazolines
创造者:
Holman, Samuel David Lee
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel heterocyclic ligands for the lipid kinase PI4KIIIβ : a chemical biology approach
创造者:
Cosgrove, Brett
日期:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New treatments for inflammatory diseases : optimisation and understanding of key processes
创造者:
Davies, Suzanne H.
日期:
2012
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry and WestCHEM
The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
创造者:
Hobbs, Michael
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
创造者:
Slack, Robert J.
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Development of lysine-targeted irreversible inhibitors of PI3Kδ
创造者:
Dalton, Samuel E.
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New chemical approaches for the development of targeted protein degradation
创造者:
Lithgow, Hannah
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
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