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GlaxoSmithKline
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Risultati della ricerca
Development of the C-methyltransferases NovO and CouO for biocatalytic Friedel-Crafts alkylation
Creatore:
Sadler, Joanna C.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
Creatore:
Harrison, Zoë A.
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Studies and improvement of molecular docking methods in rigid and flexible receptors
Creatore:
Le Gall, Armelle
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
Creatore:
Willis, Robert
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences.
Effects of OGG1 activation on mitochondrial function in response to oxidative stress
Creatore:
Katchur, Steven R.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences.
Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
Creatore:
Whitehurst, Ben.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The development of small molecule inhibitors for fibrosis drug discovery
Creatore:
Miller, Lisa Margaret
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New treatments for inflammatory diseases : optimisation and understanding of key processes
Creatore:
Davies, Suzanne H.
Data:
2012
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry. and WestCHEM.
The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
Creatore:
Campos, Sébastien André.
Data:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
Creatore:
Orr, David George Alexander.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of epigenetic mechanism inhibitors
Creatore:
Campbell, Matthew.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Automated, quantitative process analysis by NMR
Creatore:
Watson, Simon Andrew.
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
New methods for the construction of selectively difluorinated carbocycles
Creatore:
McCarter, Adam William.
Data:
2018
Funder:
GlaxoSmithKline
and
Carnegie Trust for the Universities of Scotland
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Approaches to lead generation for idiopathic pulmonary fibrosis targets
Creatore:
Duffy, Emma.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
Creatore:
Miah, Afjal Hussain
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Single electron transfer in organic synthesis targeted towards sustainable manufacture
Creatore:
Barham, Joshua Philip
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
Creatore:
Hobbs, Michael.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
Creatore:
Hardy, Charlotte.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
Creatore:
Colleville, Aymeric Pierre.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
Creatore:
Tape, Daniel Terence.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Structure-guided approaches to the design of novel autotaxin inhibitors
Creatore:
Potjewyd, Frances
Data:
2016
Funder:
Engineering and Physical Sciences Research Council
and
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigating and exploiting best practices in hit identification and hit to lead chemistry
Creatore:
Borthwick, Jennifer
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
Creatore:
Barrett, Victoria J.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design and synthesis of small molecule bromodomain inhibitors
Creatore:
Lucas, Simon Christopher Cranko Alcock
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
Creatore:
Campbell-Crawford, Matthew H. J.
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
Creatore:
Wood, Susanna Helen
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Increasing the saturation of BET inhibitors
Creatore:
Dixon, Joseph Edward
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Computational modelling of enzyme activity to speed up biocatalyst redesign
Creatore:
Dréanic, Marie-Pierre
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
Creatore:
Sanderson, James
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
Creatore:
Baker, Blake Jamie Mark
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
Creatore:
Summers, Declan M.
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
Creatore:
Griffiths, Robert Joseph
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Chan-Lam animation studies : solving the chemotype reactivity issue
Creatore:
Vantourout, Julien
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development towards prospective modelling of in vivo rabbit QTc prolongation
Creatore:
Lewis, Gareth John
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
Creatore:
Hayhow, Thomas G.
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Studies towards the synthesis and labelling of bioactive peptides
Creatore:
Stewart, Sam
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
Creatore:
White, Gemma Victoria
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
Creatore:
Taylor, Jonathan Andrew
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
Creatore:
Tame, Christopher J.
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of lysine-targeted irreversible inhibitors of PI3Kδ
Creatore:
Dalton, Samuel E.
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
Creatore:
Hyslop, Julia
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Targeted protein degradation as a new approach to drug discovery
Creatore:
Tinworth, Christopher Patrick
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New chemical approaches for the development of targeted protein degradation
Creatore:
Lithgow, Hannah
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of chemo- and regioselective reactions of boron systems
Creatore:
Clohessy, Thomas A.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
Creatore:
Wellaway, Christopher Roland
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
Creatore:
Teague, Simon Peter
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Development of chemical probes for non-BET bromodomains
Creatore:
Theodoulou, Natalie
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of novel epigenetic modulators
Creatore:
Jones, Katherine
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
Creatore:
Lacroix, Yannick
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
Creatore:
Slack, Robert J.
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Biotechnology and Biological Sciences Research Council
1
Carnegie Trust for the Universities of Scotland
1
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis
1
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Department of Pure and Applied Chemistry
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Department of Pure and Applied Chemistry.
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Strathclyde Institute of Pharmacy and Biomedical Sciences
6
Strathclyde Institute of Pharmacy and Biomedical Sciences.
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WestCHEM.
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