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GlaxoSmithKline
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Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
1 of 20
Development of lysine-targeted irreversible inhibitors of PI3Kδ
2 of 20
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
3 of 20
Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
4 of 20
Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
5 of 20
Studies towards the synthesis and labelling of bioactive peptides
6 of 20
The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
7 of 20
Development towards prospective modelling of in vivo rabbit QTc prolongation
8 of 20
Chan-Lam animation studies : solving the chemotype reactivity issue
9 of 20
Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
10 of 20
Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
11 of 20
The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
12 of 20
Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
13 of 20
Computational modelling of enzyme activity to speed up biocatalyst redesign
14 of 20
Increasing the saturation of BET inhibitors
15 of 20
Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
16 of 20
The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
17 of 20
The design and synthesis of small molecule bromodomain inhibitors
18 of 20
Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
19 of 20
Investigating and exploiting best practices in hit identification and hit to lead chemistry
20 of 20
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类型
Thesis
81
资源类型
Doctoral thesis
76
Master thesis
5
创造者
Anderson, Niall A.
1
Baker, Blake Jamie Mark
1
Barham, Joshua Philip
1
Barrett, Victoria J.
1
Bertrand, Sophie
1
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贡献者
GlaxoSmithKline
81
Jamieson, Craig
14
Kerr, William
6
Tomkinson, Nicholas
6
Watson, Allan
6
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出资者
GlaxoSmithKline
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81
Biotechnology and Biological Sciences Research Council
1
Carnegie Trust for the Universities of Scotland
1
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis
1
Engineering and Physical Sciences Research Council
1
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部门,学校或学院
Department of Pure and Applied Chemistry
53
Department of Pure and Applied Chemistry.
20
Strathclyde Institute of Pharmacy and Biomedical Sciences
6
Strathclyde Institute of Pharmacy and Biomedical Sciences.
2
WestCHEM.
1
日期
2016
18
2020
12
2018
11
2017
9
2019
8
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