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Risultati della ricerca
1.
Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
Creatore:
Wood, Susanna Helen
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
2.
Synthetic approaches to heterocyclic systems of pharmaceutical relevance
Creatore:
Green, Luke
Data:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
3.
Catalytic methods for etherification reactions
Creatore:
Whitaker, Luke
Data:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
4.
Investigating streptomyces clavuligerus linear replicons for improved clavulanic acid production
Creatore:
Mohit, Elmira
Data:
2023 and 2024
Funder:
Biotechnology and Biological Sciences Research Council
,
GlaxoSmithKline
, and
Industrial Biotechnology Innovation Centre
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
5.
The design and synthesis of small molecule bromodomain inhibitors
Creatore:
Lucas, Simon Christopher Cranko Alcock
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
6.
Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
Creatore:
Shaalan, Youssef
Data:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
7.
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
Creatore:
Tame, Christopher J.
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
8.
Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
Creatore:
Taylor, Jonathan Andrew
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
9.
Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
Creatore:
Griffiths, Robert Joseph
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
10.
Novel heterocyclic ligands for the lipid kinase PI4KIIIβ : a chemical biology approach
Creatore:
Cosgrove, Brett
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
11.
Electrochemically enabled synthesis of substituted isoxazolines
Creatore:
Holman, Samuel David Lee
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
12.
Development of lysine-targeted irreversible inhibitors of PI3Kδ
Creatore:
Dalton, Samuel E.
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
13.
The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
Creatore:
Anderson, Niall A.
Data:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
14.
αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
Creatore:
Thompson, James
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
15.
The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
Creatore:
Miah, Afjal Hussain
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
16.
The use of structure-based drug design to optimise protein-ligand interactions
Creatore:
Bertrand, Sophie
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
17.
Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
Creatore:
Slack, Robert J.
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
18.
Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
Creatore:
Hooper-Greenhill, Edward
Data:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
19.
The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
Creatore:
Hobbs, Michael.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
20.
New treatments for inflammatory diseases : optimisation and understanding of key processes
Creatore:
Davies, Suzanne H.
Data:
2012
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry. and WestCHEM.
21.
Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
Creatore:
Orr, David George Alexander.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
22.
Single electron transfer in organic synthesis targeted towards sustainable manufacture
Creatore:
Barham, Joshua Philip
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
23.
Computational modelling of enzyme activity to speed up biocatalyst redesign
Creatore:
Dréanic, Marie-Pierre
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
24.
New methods for the construction of selectively difluorinated carbocycles
Creatore:
McCarter, Adam William.
Data:
2018
Funder:
GlaxoSmithKline
and
Carnegie Trust for the Universities of Scotland
Department, School or Faculty:
Department of Pure and Applied Chemistry.
25.
Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
Creatore:
Buchanan, Helena Stubbe
Data:
2021 and 2020
Funder:
GlaxoSmithKline
and
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis
Department, School or Faculty:
Department of Pure and Applied Chemistry
26.
Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
Creatore:
Hyslop, Julia
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
27.
The development of small molecule inhibitors for fibrosis drug discovery
Creatore:
Miller, Lisa Margaret
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
28.
Development of lysine acylating small molecules for covalent kinase inhibition
Creatore:
Fournier, Julie C. L.
Data:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
29.
Chan-Lam animation studies : solving the chemotype reactivity issue
Creatore:
Vantourout, Julien
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
30.
Investigating and exploiting best practices in hit identification and hit to lead chemistry
Creatore:
Borthwick, Jennifer
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
31.
Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
Creatore:
Willis, Robert
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences.
32.
Increasing the saturation of BET inhibitors
Creatore:
Dixon, Joseph Edward
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
33.
Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
Creatore:
Sanderson, James
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
34.
Novel approaches targeting phosphoinositide 3-kinase delta
Creatore:
Spencer, Jonathan Andrew
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
35.
Studies towards the synthesis and labelling of bioactive peptides
Creatore:
Stewart, Sam
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
36.
Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
Creatore:
Williams, Jason D.
Data:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
37.
Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
Creatore:
Diallo, Hawa
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
38.
A medicinal chemistry approach towards brodomain epigenetic modulators
Creatore:
Law, Robert Peter
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
39.
The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
Creatore:
Snell, Richard
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
40.
Understanding the hepatic disposition of statins to improve predictions of safety and efficacy
Creatore:
Heslop, Teresa Louise
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
41.
New methods for the synthesis of pharmaceutical azacycles
Creatore:
Clark, Peter
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
42.
Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
Creatore:
Shah, Rishi R.
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
43.
The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
Creatore:
Lacroix, Yannick
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
44.
The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
Creatore:
Hardy, Charlotte.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
45.
The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
Creatore:
Tape, Daniel Terence.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
46.
The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
Creatore:
Hayhow, Thomas G.
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
47.
Targeted protein degradation as a new approach to drug discovery
Creatore:
Tinworth, Christopher Patrick
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
48.
New chemical approaches for the development of targeted protein degradation
Creatore:
Lithgow, Hannah
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
49.
The development of chemo- and regioselective reactions of boron systems
Creatore:
Clohessy, Thomas A.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
50.
Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
Creatore:
Wellaway, Christopher Roland
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
51.
The design and synthesis of novel epigenetic modulators
Creatore:
Jones, Katherine
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
52.
Preclinical development of a treatment for systemic lupus erythematosus
Creatore:
Murray, Erin
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
53.
The use of contemporary chemoproteomic techniques in antimalarial target identification
Creatore:
Tucker, Jessie S.
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
54.
Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
Creatore:
Priestner, John C.
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
55.
New hydrogen atom transfer methodologies for synthesis
Creatore:
Turner, Oliver
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
56.
The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
Creatore:
Harrison, Zoë A.
Data:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
57.
The design, synthesis and optimisation of epigenetic mechanism inhibitors
Creatore:
Campbell, Matthew.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
58.
Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
Creatore:
Colleville, Aymeric Pierre.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
59.
The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
Creatore:
Campbell-Crawford, Matthew H. J.
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
60.
Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
Creatore:
Summers, Declan M.
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
61.
Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
Creatore:
White, Gemma Victoria
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
62.
Development of chemical probes for non-BET bromodomains
Creatore:
Theodoulou, Natalie
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
63.
The design and synthesis of chemical probes for non-BET bromodomains
Creatore:
Clegg, Michael A.
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
64.
Application of bioisosteres to modulate molecular properties in medicinal chemistry
Creatore:
Measom, Nicholas
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
65.
The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
Creatore:
Baker, Blake Jamie Mark
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
66.
Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
Creatore:
Mahammed, Farjana
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
67.
Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
Creatore:
Fallon, David
Data:
2020
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
68.
Structure-guided approaches to the design of novel autotaxin inhibitors
Creatore:
Potjewyd, Frances
Data:
2016
Funder:
Engineering and Physical Sciences Research Council
and
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
69.
Development of the C-methyltransferases NovO and CouO for biocatalytic Friedel-Crafts alkylation
Creatore:
Sadler, Joanna C.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
70.
Studies and improvement of molecular docking methods in rigid and flexible receptors
Creatore:
Le Gall, Armelle
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
71.
Development towards prospective modelling of in vivo rabbit QTc prolongation
Creatore:
Lewis, Gareth John
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
72.
The design and synthesis of targeted BET inhibitors
Creatore:
Robertson, Craig Michael
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
73.
New route investigation and process development in the synthesis of GSK221149
Creatore:
Roberts, Alastair
Data:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
74.
Approaches to lead generation for idiopathic pulmonary fibrosis targets
Creatore:
Duffy, Emma.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
75.
Development of small molecule splice-switchers as inducers of apoptosis
Creatore:
Campbell, Emma
Data:
2021
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
76.
New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
Creatore:
Teague, Simon Peter
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
77.
Effects of OGG1 activation on mitochondrial function in response to oxidative stress
Creatore:
Katchur, Steven R.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences.
78.
Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
Creatore:
Barrett, Victoria J.
Data:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
79.
Automated, quantitative process analysis by NMR
Creatore:
Watson, Simon Andrew.
Data:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
80.
The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
Creatore:
Campos, Sébastien André.
Data:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
81.
Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
Creatore:
Whitehurst, Ben.
Data:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
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