The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
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The design and synthesis of novel epigenetic modulators
2 of 10
Development of chemical probes for non-BET bromodomains
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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The development of chemo- and regioselective reactions of boron systems
5 of 10
New chemical approaches for the development of targeted protein degradation
6 of 10
Targeted protein degradation as a new approach to drug discovery
7 of 10
Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
8 of 10
Development of lysine-targeted irreversible inhibitors of PI3Kδ
9 of 10
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases