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GlaxoSmithKline
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Development of the C-methyltransferases NovO and CouO for biocatalytic Friedel-Crafts alkylation
创造者:
Sadler, Joanna C.
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
创造者:
Harrison, Zoë A.
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Studies and improvement of molecular docking methods in rigid and flexible receptors
创造者:
Le Gall, Armelle
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
创造者:
Willis, Robert
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences.
Effects of OGG1 activation on mitochondrial function in response to oxidative stress
创造者:
Katchur, Steven R.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences.
Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
创造者:
Whitehurst, Ben.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The development of small molecule inhibitors for fibrosis drug discovery
创造者:
Miller, Lisa Margaret
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New treatments for inflammatory diseases : optimisation and understanding of key processes
创造者:
Davies, Suzanne H.
日期:
2012
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry. and WestCHEM.
The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
创造者:
Campos, Sébastien André.
日期:
2013
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
创造者:
Orr, David George Alexander.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of epigenetic mechanism inhibitors
创造者:
Campbell, Matthew.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Automated, quantitative process analysis by NMR
创造者:
Watson, Simon Andrew.
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
New methods for the construction of selectively difluorinated carbocycles
创造者:
McCarter, Adam William.
日期:
2018
Funder:
GlaxoSmithKline
and
Carnegie Trust for the Universities of Scotland
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Approaches to lead generation for idiopathic pulmonary fibrosis targets
创造者:
Duffy, Emma.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
创造者:
Miah, Afjal Hussain
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Single electron transfer in organic synthesis targeted towards sustainable manufacture
创造者:
Barham, Joshua Philip
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
创造者:
Hobbs, Michael.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
创造者:
Hardy, Charlotte.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
创造者:
Colleville, Aymeric Pierre.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
创造者:
Tape, Daniel Terence.
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Structure-guided approaches to the design of novel autotaxin inhibitors
创造者:
Potjewyd, Frances
日期:
2016
Funder:
Engineering and Physical Sciences Research Council
and
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigating and exploiting best practices in hit identification and hit to lead chemistry
创造者:
Borthwick, Jennifer
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
创造者:
Barrett, Victoria J.
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
The design and synthesis of small molecule bromodomain inhibitors
创造者:
Lucas, Simon Christopher Cranko Alcock
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
创造者:
Campbell-Crawford, Matthew H. J.
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
创造者:
Wood, Susanna Helen
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Increasing the saturation of BET inhibitors
创造者:
Dixon, Joseph Edward
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Computational modelling of enzyme activity to speed up biocatalyst redesign
创造者:
Dréanic, Marie-Pierre
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
创造者:
Sanderson, James
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
创造者:
Baker, Blake Jamie Mark
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
创造者:
Summers, Declan M.
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
创造者:
Griffiths, Robert Joseph
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Chan-Lam animation studies : solving the chemotype reactivity issue
创造者:
Vantourout, Julien
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development towards prospective modelling of in vivo rabbit QTc prolongation
创造者:
Lewis, Gareth John
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
创造者:
Hayhow, Thomas G.
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Studies towards the synthesis and labelling of bioactive peptides
创造者:
Stewart, Sam
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
创造者:
White, Gemma Victoria
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
创造者:
Taylor, Jonathan Andrew
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
创造者:
Tame, Christopher J.
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Development of lysine-targeted irreversible inhibitors of PI3Kδ
创造者:
Dalton, Samuel E.
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
创造者:
Hyslop, Julia
日期:
2018
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry.
Targeted protein degradation as a new approach to drug discovery
创造者:
Tinworth, Christopher Patrick
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New chemical approaches for the development of targeted protein degradation
创造者:
Lithgow, Hannah
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The development of chemo- and regioselective reactions of boron systems
创造者:
Clohessy, Thomas A.
日期:
2017
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
创造者:
Wellaway, Christopher Roland
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
创造者:
Teague, Simon Peter
日期:
2019
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
Development of chemical probes for non-BET bromodomains
创造者:
Theodoulou, Natalie
日期:
2016
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design and synthesis of novel epigenetic modulators
创造者:
Jones, Katherine
日期:
2014
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
创造者:
Lacroix, Yannick
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Department of Pure and Applied Chemistry
Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
创造者:
Slack, Robert J.
日期:
2015
Funder:
GlaxoSmithKline
Department, School or Faculty:
Strathclyde Institute of Pharmacy and Biomedical Sciences
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81
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76
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5
创造者
Anderson, Niall A.
1
Baker, Blake Jamie Mark
1
Barham, Joshua Philip
1
Barrett, Victoria J.
1
Bertrand, Sophie
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81
Jamieson, Craig
14
Kerr, William
6
Tomkinson, Nicholas
6
Watson, Allan
6
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Biotechnology and Biological Sciences Research Council
1
Carnegie Trust for the Universities of Scotland
1
EPSRC Centre for Doctoral Training in Technology Enhanced Chemical Synthesis
1
Engineering and Physical Sciences Research Council
1
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Department of Pure and Applied Chemistry
53
Department of Pure and Applied Chemistry.
20
Strathclyde Institute of Pharmacy and Biomedical Sciences
6
Strathclyde Institute of Pharmacy and Biomedical Sciences.
2
WestCHEM.
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