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A medicinal chemistry approach towards brodomain epigenetic modulators
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The design and synthesis of targeted BET inhibitors
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Development of chemical probes for non-BET bromodomains
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Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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Studies towards the synthesis and labelling of bioactive peptides
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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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Structure-guided approaches to the design of novel autotaxin inhibitors
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
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