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Catalytic methods for etherification reactions
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Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
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Development of lysine acylating small molecules for covalent kinase inhibition
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Novel heterocyclic ligands for the lipid kinase PI4KIIIβ : a chemical biology approach
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A medicinal chemistry approach towards brodomain epigenetic modulators
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Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
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The use of structure-based drug design to optimise protein-ligand interactions
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The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
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Electrochemically enabled synthesis of substituted isoxazolines
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αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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New methods for the synthesis of pharmaceutical azacycles
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New hydrogen atom transfer methodologies for synthesis
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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The design and synthesis of chemical probes for non-BET bromodomains
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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New route investigation and process development in the synthesis of GSK221149
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The design and synthesis of targeted BET inhibitors
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