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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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Development of small molecule splice-switchers as inducers of apoptosis
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New route investigation and process development in the synthesis of GSK221149
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The design and synthesis of targeted BET inhibitors
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Structure-guided approaches to the design of novel autotaxin inhibitors
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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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The design and synthesis of chemical probes for non-BET bromodomains
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Development of chemical probes for non-BET bromodomains
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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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New hydrogen atom transfer methodologies for synthesis
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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Preclinical development of a treatment for systemic lupus erythematosus
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The design and synthesis of novel epigenetic modulators
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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