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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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Development of small molecule splice-switchers as inducers of apoptosis
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New route investigation and process development in the synthesis of GSK221149
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The design and synthesis of targeted BET inhibitors
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Structure-guided approaches to the design of novel autotaxin inhibitors
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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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The design and synthesis of chemical probes for non-BET bromodomains
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Development of chemical probes for non-BET bromodomains
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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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New hydrogen atom transfer methodologies for synthesis
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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Preclinical development of a treatment for systemic lupus erythematosus
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The design and synthesis of novel epigenetic modulators
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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The development of chemo- and regioselective reactions of boron systems
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New chemical approaches for the development of targeted protein degradation
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Targeted protein degradation as a new approach to drug discovery
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The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
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The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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New methods for the synthesis of pharmaceutical azacycles
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The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
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A medicinal chemistry approach towards brodomain epigenetic modulators
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Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
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Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
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Studies towards the synthesis and labelling of bioactive peptides
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Novel approaches targeting phosphoinositide 3-kinase delta
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Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
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Increasing the saturation of BET inhibitors
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Chan-Lam animation studies : solving the chemotype reactivity issue
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Development of lysine acylating small molecules for covalent kinase inhibition
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The development of small molecule inhibitors for fibrosis drug discovery
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Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
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Computational modelling of enzyme activity to speed up biocatalyst redesign
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The use of structure-based drug design to optimise protein-ligand interactions
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αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
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The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
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Development of lysine-targeted irreversible inhibitors of PI3Kδ
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Electrochemically enabled synthesis of substituted isoxazolines
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Novel heterocyclic ligands for the lipid kinase PI4KIIIβ : a chemical biology approach
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Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
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Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
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The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
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Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
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