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Increasing the saturation of BET inhibitors
1 di 31
Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
2 di 31
Investigating and exploiting best practices in hit identification and hit to lead chemistry
3 di 31
Chan-Lam animation studies : solving the chemotype reactivity issue
4 di 31
Development of lysine acylating small molecules for covalent kinase inhibition
5 di 31
The development of small molecule inhibitors for fibrosis drug discovery
6 di 31
Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
7 di 31
Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
8 di 31
New methods for the construction of selectively difluorinated carbocycles
9 di 31
Computational modelling of enzyme activity to speed up biocatalyst redesign
10 di 31
Single electron transfer in organic synthesis targeted towards sustainable manufacture
11 di 31
Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
12 di 31
New treatments for inflammatory diseases : optimisation and understanding of key processes
13 di 31
The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
14 di 31
Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
15 di 31
Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
16 di 31
The use of structure-based drug design to optimise protein-ligand interactions
17 di 31
The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
18 di 31
αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
19 di 31
The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
20 di 31
Development of lysine-targeted irreversible inhibitors of PI3Kδ
21 di 31
Electrochemically enabled synthesis of substituted isoxazolines
22 di 31
Novel heterocyclic ligands for the lipid kinase PI4KIIIβ : a chemical biology approach
23 di 31
Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
24 di 31
Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
25 di 31
The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
26 di 31
Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
27 di 31
The design and synthesis of small molecule bromodomain inhibitors
28 di 31
Investigating streptomyces clavuligerus linear replicons for improved clavulanic acid production
29 di 31
Catalytic methods for etherification reactions
30 di 31
Synthetic approaches to heterocyclic systems of pharmaceutical relevance
31 di 31