Thesis
Improvements to iontophoresis devices for transdermal glucose monitoring
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2021
- Thesis identifier
- T15618
- Person Identifier (Local)
- 201253106
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- Self-monitoring of blood glucose plays a crucial role in diabetes care. Current methods apply invasive means, which causes pain and discomfort to the people with diabetes. Therefore, non-invasive methods are in high demand. Reverse Iontophoresis (RI) is a technique for non-invasive transdermal glucose monitoring. Thereby, electric current is applied across the skin to extract glucose from the interstitial fluid into a gelreservoir, where it is measured with an in situ glucose sensor. One of the key problems in RI based wearable sensors, is the glucose build-up in the gel-reservoir, which results in poor correlation between the extracted glucose and blood glucose level. Activated Carbon (AC) has excellent adsorption capabilities to organic molecules and could therefore act as a glucose binding agent in the RI devices leading to more accurate glucose readings and ultimately better correlation between the extracted and blood glucose levels. The overall aim was to study and compare glucose fluxes in in vitro RI experiments using the developed AC-integrated electrodes to the standard electrodes without AC. The extracted glucose was quantified using glucose assay kits. Furthermore, this study involved embedding a biosensor in the electrode system to allow direct glucose measurements. In vitro RI experiments using the newly developed AC-integrated electrodes showed increased glucose fluxes of 61% in the high glucose concentration level in the diffusion cell. Besides, the extracted glucose correlated well with increasing glucose concentrations in the diffusion cell (R2 =0.90). Thus, confirming AC’s suitability as a glucose binding agent in the RI environment. In vitro RI experiments with an integrated mediated enzymatic glucose sensor in the electrode system showed limited success for electrochemical glucose quantification of the extracted glucose. However, a thorough electrochemical characterisation of the developed glucose sensor using cyclic voltammetry was performed, which may provide good basis to make improvements for future glucose sensors.
- Advisor / supervisor
- Connolly, Patricia
- Resource Type
- Note
- Previously held under moratorium from 1st June 2021 until 30th June 2023.
- DOI
- Date Created
- 2021
- Former identifier
- 9912981491502996
关系
项目
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PDF of thesis T15618 | 2021-07-02 | 公开 | 下载 |