Thesis
Improvements to iontophoresis devices for transdermal glucose monitoring
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2021
- Thesis identifier
- T15618
- Person Identifier (Local)
- 201253106
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- Self-monitoring of blood glucose plays a crucial role in diabetes care. Currentmethods apply invasive means, which causes pain and discomfort to the people withdiabetes. Therefore, non-invasive methods are in high demand. Reverse Iontophoresis(RI) is a technique for non-invasive transdermal glucose monitoring. Thereby, electriccurrent is applied across the skin to extract glucose from the interstitial fluid into a gelreservoir, where it is measured with an in situ glucose sensor. One of the key problemsin RI based wearable sensors, is the glucose build-up in the gel-reservoir, which resultsin poor correlation between the extracted glucose and blood glucose level. ActivatedCarbon (AC) has excellent adsorption capabilities to organic molecules and couldtherefore act as a glucose binding agent in the RI devices leading to more accurateglucose readings and ultimately better correlation between the extracted and bloodglucose levels.The overall aim was to study and compare glucose fluxes in in vitro RIexperiments using the developed AC-integrated electrodes to the standard electrodeswithout AC. The extracted glucose was quantified using glucose assay kits.Furthermore, this study involved embedding a biosensor in the electrode system toallow direct glucose measurements.In vitro RI experiments using the newly developed AC-integrated electrodesshowed increased glucose fluxes of 61% in the high glucose concentration level in thediffusion cell. Besides, the extracted glucose correlated well with increasing glucoseconcentrations in the diffusion cell (R2=0.90). Thus, confirming AC’s suitability as aglucose binding agent in the RI environment.In vitro RI experiments with an integrated mediated enzymatic glucose sensor inthe electrode system showed limited success for electrochemical glucosequantification of the extracted glucose. However, a thorough electrochemicalcharacterisation of the developed glucose sensor using cyclic voltammetry wasperformed, which may provide good basis to make improvements for future glucosesensors.
- Advisor / supervisor
- Connolly, Patricia
- Resource Type
- Note
- Previously held under moratorium from 1st June 2021 until 30th June 2023.
- DOI
- Date Created
- 2021
- Former identifier
- 9912981491502996
关系
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PDF of thesis T15618 | 2021-07-02 | 公开 | 下载 |