Thesis

Modelling effects of ionising radiation

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Awarding institution
  • University of Strathclyde
Date of award
  • 2014
Thesis identifier
  • T13702
Qualification Level
Qualification Name
Department, School or Faculty
Abstract
  • In this thesis, we are concerned with the molecular biology processes of ionising radiation (IR) damage and its repair. In particular, we develop a mechanistic model of high dose irradiation damage to DNA in mammalian cells by considering a population of cells structured by the number of double strand breaks and mis-repairs. This framework allows us to construct a mechanistic explanation for the Linear-Quadratic (LQ) formalism. Other contributions of this thesis are a model of ataxia telangiectasia mutated (ATM) dynamics in DNA damage repair, and a discussion of bistability, an important ingredient in the construction of a general theory of non-targeted radiation effects.
Resource Type
DOI
Date Created
  • 2014
Former identifier
  • 1031353

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