Thesis
Development of a superabsorber based haemofiltration technology for use in paediatric cardiac surgery
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2016
- Thesis identifier
- T14441
- Person Identifier (Local)
- 201080778
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- Cardiopulmonary bypass is known to cause great changes in a patient’s physiological fluidhomeostasis which frequently results in fluid accumulation in the interstitial space (edema). Theassociated inflammatory response can, in severe cases, result in systemic immune responsesyndrome, acute respiratory distress syndrome, and organ failure.Modified Ultrafiltration (MUF) involves pumping blood through a haemofilter post-bypass toremove excess plasma, and has been shown to successfully moderate haemodilution and theinflammatory response and improve clinical outcomes in paediatric patients for whom edema isa serious morbidity.In this research project, the current MUF technique is combined with a new superabsorberbased haemofiltration technology to develop a novel haemofiltration device.Design concepts were researched and the optimal device configuration was determined.Laboratory testing with bovine blood, computational modelling of blood flow and scanningelectron microscope imaging of the control membrane highlighted the importance of bothutilising flow disruption techniques to limit fouling, and controlling the swelling behaviour ofthe superabsorber material, in achieving rapid haemofiltration.The device is able to achieve passive, chemically driven haemofiltration at a fixed blood flowrate and is designed such that it requires minimal input from clinical staff to be suitable fordeployment in a clinical setting. The haemoconcentration time is close to current MUFprocedures but with further refinement of the system, equalling the MUF time for currentprocedures is certainly achievable.The blood haemoconcentrated by the device was of good quality with no significant change incell counts, cell morphology measures, or haemoglobin level measures after 60mins of MUFindicating little to no impact upon the blood constituents or haemolysis induced by the device.The device did not demonstrate selective removal of pro-inflammatory mediators but similarlythere was no increase in pro-inflammatory mediator concentrations observed. Furtherinvestigation of the inflammatory mediator impact is recommended.
- Advisor / supervisor
- Gourlay, Terry
- Resource Type
- Note
- Previously held under moratorium from 30th November 2016 until 30th November 2021
- DOI
- Date Created
- 2016
- Former identifier
- 9912537087302996
Beziehungen
Objekte
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