Thesis

In Silico size effects in cancellous bone

Creator
Rights statement
Awarding institution
  • University of Strathclyde
Date of award
  • 2024
Thesis identifier
  • T17166
Person Identifier (Local)
  • 201561039
Qualification Level
Qualification Name
Department, School or Faculty
Abstract
  • Cancellous bone is a heterogeneous material with a complex lattice microstructure. The description of this microstructure in terms of the mechanical properties of cancellous bone exhibited on the macroscopic scale is important in the understanding of periprosthetic stress concentrations which eventually lead to aseptic loosening or radiolucency in implants. Micropolar elasticity is a higher order continuum theory which could potentially used to describe the influence of the microstructure of cancellous bone on its mechanical behaviour at a macroscopic scale. This theory predicts a size effect behaviour in bending and torsion while predicted no size effect behaviour in compression. This has been investigated computationally and validated experimentally using bovine distal femoral trabecular bone. Computational models of various idealised lattice models have also been analysed and compared to priorly investigated models. It was observed that the idealised lattice models exhibited size effect behaviour as predicted by micropolar theory whilst the experimental models and the computational models of cancellous bone exhibited a size effect behaviour that was opposite to that predicted by micropolar theory. The ramifications of this are that micropolar theory may not be suitable to model the size effect behaviour of trabecular bone and that further mathematical models and/or idealised lattice arrays may need to be further investigated to create a more accurate representation of trabecular bone. These findings are important because they in silico testing has been validated through experimental testing. Analysis of the stress and strain distributions also provides insight as to why size effects that are opposite to those predicted by micropolar theory have been observed both in silico and experimentally.
Advisor / supervisor
  • Wheel, Marcus
  • Riches, Philip
Resource Type
DOI
Date Created
  • 2023

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