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The use of structure-based drug design to optimise protein-ligand interactions
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New route investigation and process development in the synthesis of GSK221149
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Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
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The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
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