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The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
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The design and synthesis of novel epigenetic modulators
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Development of chemical probes for non-BET bromodomains
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New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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The development of chemo- and regioselective reactions of boron systems
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New chemical approaches for the development of targeted protein degradation
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Targeted protein degradation as a new approach to drug discovery
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Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
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Development of lysine-targeted irreversible inhibitors of PI3Kδ
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