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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
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Computational modelling of enzyme activity to speed up biocatalyst redesign
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Increasing the saturation of BET inhibitors
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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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The design and synthesis of small molecule bromodomain inhibitors
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Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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Structure-guided approaches to the design of novel autotaxin inhibitors
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
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The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
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The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
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Single electron transfer in organic synthesis targeted towards sustainable manufacture
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The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
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Approaches to lead generation for idiopathic pulmonary fibrosis targets
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New methods for the construction of selectively difluorinated carbocycles
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Automated, quantitative process analysis by NMR
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The design, synthesis and optimisation of epigenetic mechanism inhibitors
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Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
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The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
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New treatments for inflammatory diseases : optimisation and understanding of key processes
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The development of small molecule inhibitors for fibrosis drug discovery
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Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
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Effects of OGG1 activation on mitochondrial function in response to oxidative stress
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Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
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Studies and improvement of molecular docking methods in rigid and flexible receptors
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The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
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Development of the C-methyltransferases NovO and CouO for biocatalytic Friedel-Crafts alkylation
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