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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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The design and synthesis of chemical probes for non-BET bromodomains
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New hydrogen atom transfer methodologies for synthesis
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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New methods for the synthesis of pharmaceutical azacycles
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Understanding the hepatic disposition of statins to improve predictions of safety and efficacy
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The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
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A medicinal chemistry approach towards brodomain epigenetic modulators
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Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
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Development of lysine acylating small molecules for covalent kinase inhibition
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Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
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New treatments for inflammatory diseases : optimisation and understanding of key processes
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The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
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Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
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Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
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The use of structure-based drug design to optimise protein-ligand interactions
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