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The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
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The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
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Studies towards the synthesis and labelling of bioactive peptides
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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Structure-guided approaches to the design of novel autotaxin inhibitors
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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Investigation of LPA₁ receptor antagonism / ATX inhibition by a scaffold hopping aproach and SAR analysis
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The development of natural products as phytotoxic leads for herbicide discovery
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Development of novel allosteric regulators of proteinase-activated receptors
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Investigations into the generation and pleiotropic reactivity modes of the nitrile imine 1,3-dipole
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