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Synthesis and biological evaluation of novel small molecule bromodomain inhibitors
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Automated, quantitative process analysis by NMR
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Understanding the hepatic disposition of statins to improve predictions of safety and efficacy
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
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The design and synthesis of chemical probes for non-BET bromodomains
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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Development and understanding of rhodium-catalysed conjugate arylation for process chemistry applications
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New chemical approaches for the development of targeted protein degradation
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