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Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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Chan-Lam animation studies : solving the chemotype reactivity issue
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Development of lysine acylating small molecules for covalent kinase inhibition
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The development of small molecule inhibitors for fibrosis drug discovery
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Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
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Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
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New methods for the construction of selectively difluorinated carbocycles
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Computational modelling of enzyme activity to speed up biocatalyst redesign
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Single electron transfer in organic synthesis targeted towards sustainable manufacture
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Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
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New treatments for inflammatory diseases : optimisation and understanding of key processes
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The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
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Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
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Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
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The use of structure-based drug design to optimise protein-ligand interactions
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The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
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αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
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The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
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Development of lysine-targeted irreversible inhibitors of PI3Kδ
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Electrochemically enabled synthesis of substituted isoxazolines
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Novel heterocyclic ligands for the lipid kinase PI4KIIIβ : a chemical biology approach
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Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
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Novel PI3Kδ inhibitors for the treatment of inflammatory diseases
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The design and synthesis of αvβ6 antagonists and PI3K inhibitors as small molecule therapies for respiratory diseases
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Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
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The design and synthesis of small molecule bromodomain inhibitors
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Investigating streptomyces clavuligerus linear replicons for improved clavulanic acid production
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Catalytic methods for etherification reactions
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Synthetic approaches to heterocyclic systems of pharmaceutical relevance
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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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