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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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The design, synthesis and optimisation of epigenetic mechanism inhibitors
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Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
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The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
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New hydrogen atom transfer methodologies for synthesis
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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Preclinical development of a treatment for systemic lupus erythematosus
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The design and synthesis of novel epigenetic modulators
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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The development of chemo- and regioselective reactions of boron systems
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New chemical approaches for the development of targeted protein degradation
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Targeted protein degradation as a new approach to drug discovery
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The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
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The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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