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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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The design and synthesis of chemical probes for non-BET bromodomains
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Development of chemical probes for non-BET bromodomains
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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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New hydrogen atom transfer methodologies for synthesis
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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Preclinical development of a treatment for systemic lupus erythematosus
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