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Increasing the saturation of BET inhibitors
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Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
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Novel approaches targeting phosphoinositide 3-kinase delta
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Studies towards the synthesis and labelling of bioactive peptides
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Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
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Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
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A medicinal chemistry approach towards brodomain epigenetic modulators
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The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
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Understanding the hepatic disposition of statins to improve predictions of safety and efficacy
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New methods for the synthesis of pharmaceutical azacycles
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
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The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
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Targeted protein degradation as a new approach to drug discovery
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New chemical approaches for the development of targeted protein degradation
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The development of chemo- and regioselective reactions of boron systems
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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The design and synthesis of novel epigenetic modulators
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