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Electrochemically enabled synthesis of substituted isoxazolines
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Development of lysine-targeted irreversible inhibitors of PI3Kδ
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The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
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αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
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The design, synthesis and optimisation of CCR4 antagonists for the treatment of asthma
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The use of structure-based drug design to optimise protein-ligand interactions
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Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
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Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
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The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
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New treatments for inflammatory diseases : optimisation and understanding of key processes
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