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The design and synthesis of novel epigenetic modulators
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Preclinical development of a treatment for systemic lupus erythematosus
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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New hydrogen atom transfer methodologies for synthesis
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The design, synthesis and optimisation of kinase inhibitors as potential anti-inflammatory agents
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The design, synthesis and optimisation of epigenetic mechanism inhibitors
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Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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Development of chemical probes for non-BET bromodomains
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The design and synthesis of chemical probes for non-BET bromodomains
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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Structure-guided approaches to the design of novel autotaxin inhibitors
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Development of the C-methyltransferases NovO and CouO for biocatalytic Friedel-Crafts alkylation
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Studies and improvement of molecular docking methods in rigid and flexible receptors
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Development towards prospective modelling of in vivo rabbit QTc prolongation
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The design and synthesis of targeted BET inhibitors
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New route investigation and process development in the synthesis of GSK221149
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Approaches to lead generation for idiopathic pulmonary fibrosis targets
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Development of small molecule splice-switchers as inducers of apoptosis
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New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
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Effects of OGG1 activation on mitochondrial function in response to oxidative stress
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Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
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Automated, quantitative process analysis by NMR
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The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
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Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
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