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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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The design and synthesis of small molecule bromodomain inhibitors
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Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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Structure-guided approaches to the design of novel autotaxin inhibitors
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
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The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
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The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
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