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Computational modelling of enzyme activity to speed up biocatalyst redesign
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Increasing the saturation of BET inhibitors
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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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New hydrogen atom transfer methodologies for synthesis
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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Chan-Lam animation studies : solving the chemotype reactivity issue
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
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The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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Investigating streptomyces clavuligerus linear replicons for improved clavulanic acid production
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Development of lysine acylating small molecules for covalent kinase inhibition
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Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
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Novel approaches targeting phosphoinositide 3-kinase delta
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The design and synthesis of targeted BET inhibitors
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Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
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The design and synthesis of small molecule bromodomain inhibitors
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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