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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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Understanding the hepatic disposition of statins to improve predictions of safety and efficacy
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New hydrogen atom transfer methodologies for synthesis
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New methods for the synthesis of pharmaceutical azacycles
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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
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αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
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Electrochemically enabled synthesis of substituted isoxazolines
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The design, synthesis and optimisation of αvβ6 antagonists as potential idiopathic pulmonary fibrosis agents
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The use of structure-based drug design to optimise protein-ligand interactions
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The development and evaluation of a method for the quantitative determination of a monoclonal antibody using capillary electrophoresis-high resolution mass spectrometry
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Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
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A medicinal chemistry approach towards brodomain epigenetic modulators
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Novel heterocyclic ligands for the lipid kinase PI4KIIIβ : a chemical biology approach
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Development of lysine acylating small molecules for covalent kinase inhibition
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Homogeneous hydrogenation and photochemistry as tools in pharmaceutical process development
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Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
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Synthetic approaches to heterocyclic systems of pharmaceutical relevance
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Investigating streptomyces clavuligerus linear replicons for improved clavulanic acid production
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