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Targeted protein degradation as a new approach to drug discovery
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New chemical approaches for the development of targeted protein degradation
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The development of chemo- and regioselective reactions of boron systems
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
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Development of chemical probes for non-BET bromodomains
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The design and synthesis of novel epigenetic modulators
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The design, synthesis and optimisation of calcium release-activated calcium (CRAC) channel inhibitors and mitochondrial permeability transition pore (mPTP) modulators, using phenotypic screening
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Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
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Development of small molecule splice-switchers as inducers of apoptosis
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Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
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Novel approaches targeting phosphoinositide 3-kinase delta
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Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
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The design and synthesis of targeted BET inhibitors
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New route investigation and process development in the synthesis of GSK221149
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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The design and synthesis of chemical probes for non-BET bromodomains
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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Hi-JAK-ing the ubiquitin system : the design and physicochemical optimisation of JAK PROTACs
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