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Synthesis and optimisation of novel molecules to probe epigenetic mechanisms with applications in the treatment of inflammatory disorders
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Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
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Studies towards the synthesis and labelling of bioactive peptides
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Novel approaches targeting phosphoinositide 3-kinase delta
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Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
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Increasing the saturation of BET inhibitors
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Mechanistic pharmacokinetic / pharmacodynamic modelling of acute inflammatory challenge models
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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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Chan-Lam animation studies : solving the chemotype reactivity issue
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Development of lysine acylating small molecules for covalent kinase inhibition
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The development of small molecule inhibitors for fibrosis drug discovery
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Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
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Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
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New methods for the construction of selectively difluorinated carbocycles
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Computational modelling of enzyme activity to speed up biocatalyst redesign
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Single electron transfer in organic synthesis targeted towards sustainable manufacture
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Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems : a computational and experimental study
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The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro
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Early application of mechanistic PKPD modelling to guide the preclinical development of a therapeutic mAb targeting complement receptor 2 (CR2/CD21) as a novel target for the treatment of autoimmune disease
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Pharmacological characterisation of small molecule RGD-mimetics targeting αvβ6-mediated activation of TGFβ in idiopathic pulmonary fibrosis
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