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Iridium-catalysed hydrogen isotope exchange of n-heterocycles and nucleosides
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Catalytic methods for etherification reactions
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New approaches in iridium catalysis for sp3 hydrogen isotope exchange of amino acid and peptides
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Structure activity studies of aminoindole anti-malarial agents to enhance physicochemical properties and safety profile
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New iridium-catalysed methods for the hydrogen isotope exchange of pharmaceutically-relevant compounds
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Investigation into novel antibacterial agents that will bind at GyrA/ParC or GyrB/ParE subunits of DNA gyrase/topoimerase IV
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Advances in the synthesis and application of iridium (I) complexes for use in hydrogen isotope exchange
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Novel methods to access tracelessly labelled molecules via iridium-catalysed hydrogen isotope exchange
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Synthesis enabled drug discovery
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αV integrin antagonists for the treatment of idiopathic pulmonary fibrosis
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Investigations into the selectivity of iridium catalysts in the hydrogen isotope exchange of aromatic aldehydes and in hydroxyl-directed stereoselective hydrogenation
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The design and synthesis of targeted BET inhibitors
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Novel C-C bond formation strategies for access to secondary and tertiary amides enabled by new synthetic technologies
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Design and synthesis of dimethylisoxazole quinolines as BET inhibitors
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Targeted protein degradation as a new approach to drug discovery
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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Novel applications of magnesium base systems in preparative organic chemistry and asymmetric synthesis
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Iridium(I) complexes for the functionalisation of carbon-hydrogen bonds
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Computationally guided rational ligand design of novel iridium (I) complexes for elevated substrate applicability in hydrogen isotope exchange processes
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