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2016
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Department of Pure and Applied Chemistry.
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Thesis
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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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Towards the rational development of organic super electron donors for transition metal-free biaryl coupling
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Electrically-induced degradation of polyester films for photovoltaic devices
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Ruthenium picolinates for photosensitisation of heterogeneous water oxidation
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Applications of the Pauson-Khand reaction in the synthesis of tricyclic sesquiterpene natural products
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Functionalisation of hollow gold nanosperes for use as stable, red-shifted SERS nanotags in bio-imaging
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Investigation into a magnetic nanoparticle-based molecular diagnostic assay
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Simultaneous detection of multiple explosives using surface enhanced Raman scattering
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Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
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The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
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The interplay of multiple ADME mechanisms, prediction of hepatic drug-drug interactions from in vitro
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Synthesis of functionalised, crosslinked polymer networks
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An exploration of alkali metal ferrate chemistry : synthesis and exploitation for N-heterocyclic carbene and fluoroarene functionalisation
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New Frontiers on Cooperative Chemistry of Rarely Employed Metals
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Development of analytical techniques for detection and remediation of polychlorinated biphenyls in soil and water samples
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Novel methods for the detection of historical biocidal residues in heritage environments
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An investigation of the distribution, fractionation and bioaccessibility of potentially toxic elements in urban soils of Lagos, Nigeria
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Investigating the binding mode of azide labelled derivatives of Hoechst 33258 by NMR, UV-Vis and IR spectroscopy
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Approaches to lead generation for idiopathic pulmonary fibrosis targets
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Development of a peptide hydrogel with tuneable stiffness to support culture of functional β-cells (MIN6 cells)
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Development of new catalytic processes for organic chemistry
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The design, synthesis and optimisation of epigenetic mechanism inhibitors
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Utilisation of rearrangement chemistry in the synthesis of novel fluorinated ring systems, a computational and experimental study
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Hydrogenation and hydrogen isotope exchange, novel, selective catalyst and process development
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White lighting, an assessment of different organic, hybrid, non-conventional and theoretical methods
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Oxidations with endocyclic peroxides and their derivatives
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Development of novel inhibitors of carbohydrate-processing targets involved in Mycobacterium tuberculosis cell wall biosynthesis
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Building a rational model for the identification of allosteric sites
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Discovery of minimalistic biocatalysts via biocatalytic self-assembly
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Peptide functionalisation and characterisation of gold (nano) surfaces
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Hollow gold nanoshells as unique near infrared optical materials for surface enhanced Raman scattering
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The development of analytical approaches to profile Scotch Whisky colour
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Development of site-specific RNA labeling strategies to probe alternative RNA splicing
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Chiral concepts in s-block metal chemistry
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Modelling short peptides in solution and at the interface
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Metal-free C-H functionalisation methods
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UV stabilisation of poly(ethylene terephthalate)
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Synthesis of multicomponent heavy alkali metal amide systems and extensions to zirconium chemistry
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The untargeted kinome, building chemical capacities and bridges in cancer research
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Protein microenvironments for topology analysis
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SERS-based nanoparticle biodetection using carbohydrate-lectin interactions
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Design and synthesis of molecular tools for the ubiquitin proteasome system
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Exploring new reactions with Organic Electron Donors and the complexities of the Birch reduction
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Extraction methods for assessing the bioaccessibility of potentially toxic elements in urban airborne particulate matter by inductively coupled plasma mass spectrometry
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Small molecules based on novel electron-deficient acceptor units for organic electronic applications
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