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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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Development of small molecule splice-switchers as inducers of apoptosis
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New route investigation and process development in the synthesis of GSK221149
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The design and synthesis of targeted BET inhibitors
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Structure-guided approaches to the design of novel autotaxin inhibitors
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Development of photoaffinity labelling technologies for small molecule drug discovery - a case study targeting bromodomains
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Application of electrochemical based sensors in support of toxicokinetic and pharmacokinetics
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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The design and synthesis of chemical probes for non-BET bromodomains
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