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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
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The design and synthesis of small molecule bromodomain inhibitors
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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Increasing the saturation of BET inhibitors
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Computational modelling of enzyme activity to speed up biocatalyst redesign
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Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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