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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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Studies towards the synthesis and labelling of bioactive peptides
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The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
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Development towards prospective modelling of in vivo rabbit QTc prolongation
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Chan-Lam animation studies : solving the chemotype reactivity issue
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Chemoselective C-H functionalisation of aliphatic azacycles : utilisation of electrophilic iodine as a mild oxidant
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Investigation and application of 3-Oxabicyclo[4.1.0]heptane as a mechanistic target of rapamycin (mTOR) kinase hinge binding fragment
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The application of flow chemistry to the synthesis of pharmaceutically privileged heterocycles
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Iron-catalysed cross-couplings of secondary alkyl Grignard reagents
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Computational modelling of enzyme activity to speed up biocatalyst redesign
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Increasing the saturation of BET inhibitors
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Understanding reaction mechanisms and structure/reactivity relationships in the electrophilic fluorination of enol esters
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The development of small molecules for treatment of idiopathic pulmonary fibrosis (IPF)
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The design and synthesis of small molecule bromodomain inhibitors
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Pharmacological characterisation of the 5-HT receptors present on mouse and human hepatic stellate cells and their role in liver fibrosis
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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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Structure-guided approaches to the design of novel autotaxin inhibitors
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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Sustainable cross-couplings for pharmaceutical scale-up using aryldiazonium salts
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The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents
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