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New methods for the synthesis of pharmaceutical azacycles
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Novel biocatalytic strategies for the synthesis of N-functionalised amino acids
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Development of chemical probes for non-BET bromodomains
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The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
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Studies towards the synthesis and labelling of bioactive peptides
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Catalytic methods for etherification reactions
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Application of bioisosteres to modulate molecular properties in medicinal chemistry
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The design and synthesis of chemical probes for non-BET bromodomains
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Investigations of the synthesis and properties of romodomain and extra-terminal domain proteolysis targeting chimeras
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The use of contemporary chemoproteomic techniques in antimalarial target identification
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Targeted protein degradation as a new approach to drug discovery
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The development of chemo- and regioselective reactions of boron systems
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New dose estimation methods and their application in early drug discovery using intravenous, oral and inhaled routes of administration for new chemical entities
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Investigating and exploiting best practices in hit identification and hit to lead chemistry
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The synthesis and optimisation of toll-like receptor agonists as potential immunomodulatory agents
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Development of small molecule splice-switchers as inducers of apoptosis
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Use of fragment-based drug discovery to identify novel drug molecules for challenging biological targets, including protein-protein interactions
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A medicinal chemistry approach towards brodomain epigenetic modulators
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Synthesis of non-natural base-pairs : towards site-specific functionalisation of nucleic acids
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Structure-guided approaches to the design of novel autotaxin inhibitors
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