Thesis

Novel strategies for optimising drug release from medicinal implants

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Awarding institution
  • University of Strathclyde
Date of award
  • 2012
Thesis identifier
  • T13250
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Abstract
  • In-stent restenosis (ISR) is a significant limitation of percutaneous coronary revascularisation procedures, occurring in around 30% of patients. Implantation of the sent produces an intense inflammatory response. This leads to high levels of smooth muscle cell (SMC) proliferation and migration, resulting in the development of a neointima, which renarrows the artery lumen. Drug-eluting stents (DES) release drugs to inhibit SMC proliferation and have been very successful in reducing ISR rates. However, they are not suitable for every patient group and lesion type, and may induce delayed healing of the endothelium, leading to a risk of late stent thrombosis. There is thus a need to develop more effective drug-eluting stents. Emerging evidence suggests that oxidative stress plays a key role in in-stent restenosis. Polypyrrole is a biocompatible conducting polymer which can act as an antioxidant and is therefore a promising material for use in DES. It can also incorporate anionic molecu les during synthesis. Salicylate is an anionic molecule with anti-inflammatory properties and which has also demonstrated anti-proliferative effects on SMC. This project investigated the possibility of creating a polypyrrole stent coating, which has the ability to release salicylate over a therapeutically relevant period of time. A series of polypyrrole coatings were produced on stainless steel by either potentiostatic or cyclic voltammetry electropolymerisation. The surface characteristics of these coatings was then determined using Scanning Electron Microscopy. Finally, the coatings were immersed in physiological solution and salicylate release quantified at various time points up to 28 days, using UV-spectroscopy. In this project we found that there may be a relationship between the coating method chosen, the characteristics of the surface and the drug release profile generated. By varying the parameters of the coating process, it should be possible in future to modify the drug release profile of the coating.
Resource Type
DOI
Date Created
  • 2012
Former identifier
  • 948098

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