Thesis
Exploiting cooperative effects in s-Block organometallics for new applications in synthesis and catalysis
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2017
- Thesis identifier
- T14621
- Person Identifier (Local)
- 201369876
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- Focussing on group 1 and group 2 metals, this thesis advances the use of polar organometallics in catalysis, in particular intermolecular hydroamination processes; as well as other key stoichiometric transformations, namely deprotonative metallation and C-F bond activation.Group 1 alkyl compounds MCH2SiMe3 (M = Li, Na or K) have proved to be efficient catalysts for intermolecular hydroamination of a wide range of substituted vinylarenes and alkynes at room temperature and with short timescales. Similarly,advancing in the concept of s-block cooperative bimetallic catalysis, alkali-metal magnesiate complexes [MMg(CH2SiMe3)3] and [(donor)2M2Mg(CH2SiMe3)4] (M = Li,Na or K) have shown that they can also act as catalysts for these hydroamination processes, although longer times and high temperature conditions are required in some cases. Reactivity studies show an alkali-metal effect with potassium being significally more reactive than lithium. New insights into the constitution of the potential organometallic intermediates involved in these processes have also been gained by combining X-Ray crystallographic and NMR studies (including DOSY NMR).The second part of this thesis assesses cooperative effects of single-metal organomagnesium complexes in deprotonation and C-F bond activation processes.Using a specially designed metallating base, which combines within the same molecule a sterically demanding β-diketiminate ligand with a kinetically activatedTMP base [DippNacnacMg(TMP)], regioselective magnesiation of heterocyclic and aromatic molecules, including pyrazine or 1,2,4,5-tetrafluorobenzene, can be achieved at room temperature. Structural studies of these metallated intermediates have revealed a crucial stabilising role of the β-diketiminate ligand, which facilitates the trapping of the sensitive anions formed. Additionally, they have provided important clues to rationalise the stability of these species in solution. Contrastingly [DippNacnacMg(THF)Bu] complex is a much more kinetically retarded base, which fails to metallate these substrates promoting in some cases, when confronted with fluoroarenes, C-F bond activation process via nucleophilic aromatic substitution.
- Resource Type
- Note
- This thesis was previously restricted to Strathclyde users only from 10 July 2017 until 1 August 2022.
- DOI
- Date Created
- 2017
- Former identifier
- 9912557293302996
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