Thesis
Polymorphism of mephedrone
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2013
- Thesis identifier
- T13557
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- The compressed crystal structure of (±)-4'-methylmethcathinone sulfate and (±)- 4'-methylmethcathinone hydrobromide form I and form II are performed by single Xray diffraction. (±)-4'-methylmethcathinone sulfate which is the least stable forms undergoes two phase transitions on compression to 5.5 GPa. The first phase transition occurs at 0.87 GPa to a phase that crystallisaes in monoclinic P21/c with cell parameters a = 11.280 (2) Å, b = 8.9046 (8) Å, c = 12.3740 (8) Å, β = 101.230 (9)° and volume = 1219.0 (3) ų. The distinct change is the rotation of hydrogen sulfate which accounts more intercalation of (±)-4'-methylmethcathinone cation. The second phase transition is likely to emerge at 5.5 GPa; however, the unit cell parameters cannot be defined. (±)-4'- methylmethcathinone hydrobromide form I is also obtained a phase transition at 1.1 GPa in monoclinic P21/c with unit cell parameters a = 5.8185 (4) Å, b = 18.6624 (18) Å, c = 10.2720 (11) Å, β = 100.174 (5)° and volume = 1097.87 (18) Å3. During the compression, the steric effect from the methyl group and oxygen atom (O9) causes the elongation of a-axis and the reduction of beta angle. At 0-1 GPa, (±)-4'- methylmethcathinone hydrobromide form II is more stable than form I. Both forms show good compressibility and have similar volume at pressure above 1 GPa. So it cannot determine which form should be favored to be stable at elevated pressure. (±)-4'- methylmethcathinone hydrochloride demonstrated a significant change of carbonyl stretch in Raman spectra between 0.1-0.63 GPa but crystallographic data have not been solved due to time constraint.
- Resource Type
- DOI
- Date Created
- 2013
- Former identifier
- 1001377