Thesis
Modelling effects of ionising radiation
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2014
- Thesis identifier
- T13702
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- In this thesis, we are concerned with the molecular biology processes of ionising radiation (IR) damage and its repair. In particular, we develop a mechanistic model of high dose irradiation damage to DNA in mammalian cells by considering a population of cells structured by the number of double strand breaks and mis-repairs. This framework allows us to construct a mechanistic explanation for the Linear-Quadratic (LQ) formalism. Other contributions of this thesis are a model of ataxia telangiectasia mutated (ATM) dynamics in DNA damage repair, and a discussion of bistability, an important ingredient in the construction of a general theory of non-targeted radiation effects.
- Resource Type
- DOI
- Date Created
- 2014
- Former identifier
- 1031353
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