Thesis

Chromosome segregation during Streptomyces coelicolor growth and development

Creator
Rights statement
Awarding institution
  • University of Strathclyde
Date of award
  • 2014
Thesis identifier
  • T13959
Qualification Level
Qualification Name
Department, School or Faculty
Abstract
  • In Streptomyces coelicolor DNA segregation is, in part, controlled by the proteins ParA and ParB. Segregation is achieved by ParB binding to parS sites, located near oriC on the bacterial chromosome, and ParA providing the separation energy for segregation. Several mutant strains containing a fluorescently tagged oriC and deletions in parA or parB were created and their growth and positioning of chromosomes, as seen by fluorescent microscopy, were studied over the different stages of its life cycle. Here I show the various differences caused by these mutations within S. coelicolor and highlight potential roles of the Par proteins in dictating the size of spores.
Resource Type
DOI
Date Created
  • 2014
Former identifier
  • 1217355

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