Visible-light-mediated annulations and rearrangements for the amination of electron-rich aromatics

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Abstract

The work described in this thesis is divided into 4 chapters including a general introduction. Each chapter is preceded by an introduction which includes the rationale behind the research and outlines the relevant background to the field. Chapter 1 is a general introduction detailing the importance of aniline derivatives, approaches to C–N bond formation, amination of methoxyarenes and a brief introduction into photoredox catalysis. Chapter 2 describes annulation reactions via methoxy displacement for the formation of tetrahydroquinolines. [Illustrative figure in thesis text] Chapter 3 investigates a radical-cation promoted photo-Smiles rearrangement. Chapter 4 expands this idea to the formation of benzomorpholines via a C–H functionalisation pathway.

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Previously held under moratorium in Chemistry Department (GSK) from 22nd September 2022 until 22nd October 2024.

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The digital version of this thesis is restricted to Strathclyde users only until 22nd September 2027.

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