Thesis
Strathclyde minor groove binders : exploring biphenyl head groups
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2026
- Thesis identifier
- T18207
- Person Identifier (Local)
- 202364002
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- In modern medicine, there is perhaps no more significant discovery than antibiotics. Their use has resulted in a substantial reduction in deaths caused by bacterial infections. Following the discovery of penicillin by Alexander Flemming in 1928, there was a boom in antibiotic discovery between the 1930s and 1950s - the ‘golden era of antibiotics. Unfortunately, a lack of understanding of the consequences of their use, combined with the massive spike in infection caused by the Second World War, led to overuse and misuse. This is still a problem today, and misuse of antibiotics is a concern in, for example, healthcare, agriculture, and water treatment. A consequence of this misuse is the ever-growing problem of antimicrobial resistance (AMR). The World Health Organization (WHO) in their 2014 antimicrobial resistance global report on surveillance described the “post-antibiotic era” where everyday injuries could be potentially fatal as “far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century”. A separate report in 2019 on the Global Burden of bacterial antimicrobial resistance found that AMR alone was directly responsible for 1.27 million deaths and was a contributing factor to 4.95 million deaths globally in 2019 alone.3 While AMR is a problem faced by every country, those who are less affluent are most affected. A report from the World Bank Group stated that AMR will cost US$ 1-3.4 trillion in gross domestic product (GDP) losses annually by 2030 with an additional US$ 1 trillion additional healthcare costs by 2050. Therefore, it is reasonable to assume that poverty will exacerbate AMR issues. However, this does not mean that these effects will not be felt by wealthier countries, as shown by the Centre for Disease Control (CDC) 2019 AMR threat report showing that microbes which are resistant to antibiotics are responsible for 35,000 deaths and 2.8 million illnesses per year in the U.S. alone. Although the AMR threat is mainly viewed through the lens of bacterial infections, other infectious organisms are a growing problem. For example, this has recently been recognised by the WHO through their publishing of a fungal pathogen threat list
- Advisor / supervisor
- Scott, Fraser
- Resource Type
- DOI
- Embargo Note
Relations
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File | 2026-10-13 | Embargo |