Thesis
Cancer phototherapy with precisely defined and highly functionalized phthalocyanine photosensitizers
- Creator
- Rights statement
- Awarding institution
- University of Strathclyde
- Date of award
- 2023
- Thesis identifier
- T16753
- Person Identifier (Local)
- 201992847
- Qualification Level
- Qualification Name
- Department, School or Faculty
- Abstract
- The thesis describes the development of regioregular phthalocyanines and is split into five chapters that describes the regioselective synthesis, determination of photophysical properties and application as phototherapeutic agents. Chapter 1 provides an overview of the necessary topics with sufficient background theory for the full appreciation of the proceeding chapters. Firstly, the core concepts of molecular photophysics are discussed followed by the fundamentals of phototherapy with photodynamic and photothermal therapy discussed in detail. Finally, an overview of phthalocyanine macrocycles highlights the challenges of a regioselective design with literature precedence of successful examples. Chapter 2 delineates the results of a C4h regioselective synthetic toolkit that allows the user to design highly functionalized, regioisomerically pure, phthalocyanines. The attempts to extend the methodology towards a similar D2h toolkit is also explored. Chapter 3 discusses the photophysical properties of the molecules synthesized within chapter 2 whilst providing comparisons between the properties of isomeric mixtures and their isomerically pure counterparts. Computational modelling of a small array of phthalocyanines was also employed compare the photophysical properties of C4h, D2h, C2v and Cs isomers to discern the influence of symmetry upon analogous phthalocyanines. Chapter 4 displays the results upon utilizing two of the synthesized phthalocyanines as phototherapeutic agents. This is further followed by the use of stimulated Raman spectroscopy as an investigative tool to provide real time insight into the cellular mechanisms behind synergistic photodynamic and photothermal damage. Chapter 5 provides the experimental protocols behind this body of work coupled with appended data of significant results that do not fit into the context of this thesis. Finally, a review article written during the initial SARS-CoV-2 lockdown is also attached as a separate body of work that lies outside the scope of this thesis but chronicles the potential benefits of chemotherapeutic appendages upon the phthalocyanine macrocycle to provide targeting and localized damage to specific organelles.
- Advisor / supervisor
- Edkins, Robert M.
- Resource Type
- Note
- This thesis was previously held under moratorium from 2nd November 2023 until 2nd November 2025.
- DOI
- Embargo Note
Relations
Items
| Thumbnail | Title | Date Uploaded | Visibility | Actions |
|---|---|---|---|---|
|
|
File | 2023-11-02 | Embargo |